Amari Cooper, recently traded from the Cleveland Browns, made an immediate impact in his first game with the Bills. Cooper scored a touchdown on one of his four catches, accumulating 66 yards in total. His presence on the field also opened up opportunities for other players, notably rookie Keon Coleman, who amassed 125 receiving yards. Cooper's integration into the Bills' offense was smooth, despite the short preparation time, indicating promising prospects for the team's aerial attack in future games.

The Tennessee Titans faced another tough game, dropping to a 1-5 record. The Titans started with a promising 10-0 lead, but their performance dwindled as the game progressed. Quarterback Mason Rudolph, filling in for the injured Will Levis, struggled with the Bills' aggressive defense, which recorded multiple sacks and quarterback pressures. The Titans' inability to maintain their early momentum and the ongoing adjustments in their lineup underscore the challenges they face in turning their season around.

The Buffalo Bills' defense was particularly impressive in the second half, where they completely shut down the Titans' offense. Defensive end Greg Rousseau was a standout performer, contributing significantly with sacks and tackles for loss. The Bills' defense not only prevented the Titans from scoring in the second half but also consistently put pressure on their quarterback, showcasing a level of dominance that could be crucial for their success in the remainder of the season.