Hannah Jiles candidly addressed the rumors that she was using Ozempic, a popular GLP-1 medication, to aid in her weight loss. In an interview, she revealed that she did try Ozempic but had to discontinue its use due to severe side effects that made her ill. She expressed regret that she couldn't continue with it, despite its potential benefits, because of how sick it made her feel.

Beyond the brief trial with Ozempic, Hannah Jiles emphasized that her weight loss and health improvements were largely due to lifestyle changes. She has focused on being more active and reevaluating her relationship with food. Jiles mentioned incorporating activities like Pilates and yoga into her routine, which she prefers over more strenuous exercises like running.

The transformation of Hannah Jiles not only sparked rumors but also highlighted the pressures and scrutiny public figures face regarding their appearance. Jiles discussed how weight-related insecurities discussed on the show motivated her to make changes. She also addressed the criticism and disbelief from the public, stressing that her efforts were genuine and driven by personal health goals.