Frank Fritz became a household name through 'American Pickers', a show that debuted in 2010. Alongside Mike Wolfe, Fritz traveled across the U.S., exploring forgotten relics and antiques in various nooks of the country. Their adventures not only brought forgotten pieces of history to light but also entertained millions with their dynamic and humorous interaction. Fritz's keen eye for rare finds and his engaging personality made him a favorite among viewers.

In his later years, Frank Fritz faced significant health challenges, including a debilitating stroke in 2022 that largely kept him out of the public eye. He spent his final months in a hospice in Davenport, Iowa, where he passed away surrounded by friends and family, including his long-time co-star and friend, Mike Wolfe. His struggle with health issues, including Crohn's disease, marked a tough phase in his life, overshadowing his vibrant career.

Following his passing, tributes poured in from fans, friends, and colleagues, highlighting his impact both on and off the screen. Mike Wolfe, in a heartfelt Instagram post, remembered Fritz as a 'dreamer' who was just as genuine off-camera as he was on. The 'American Pickers' show and its community expressed deep sorrow, emphasizing how deeply Fritz will be missed. His legacy is remembered through the countless antiques he discovered and the many lives he touched.