The season premiere of 'Only Murders in the Building' opens with a shocking twist — Sazz Pataki, portrayed by Jane Lynch, is seemingly murdered, and her body disappears without a trace. As the trio delves into the investigation, they encounter a series of cryptic clues and sinister cover-ups, suggesting a deeper conspiracy at play. The disappearance sets off a flurry of fan theories and deepens the narrative complexity, keeping the audience guessing at every turn.

Amidst the dark unfolding mystery, the trio receives an aggressive offer from Paramount Pictures to adapt their podcast into a movie. This subplot introduces a humorous take on Hollywood negotiations, with celebrity cameos including Meryl Streep, Eva Longoria, and Eugene Levy, who bring additional charm and challenges to the trio's dynamic. The Hollywood angle not only adds a meta-layer to the narrative but also explores the impact of their investigative podcast reaching a broader audience.

Season 4 not only brings back beloved characters but also introduces new ones, each adding depth and intrigue to the storyline. Michael Cyril Creighton's character, Howard, now a series regular, starts his own podcast, adding a quirky subplot. The season promises to maintain its engaging mix of humor and mystery, with the star-studded cast providing both comedic and dramatic prowess that fans have come to expect from the series.